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Article

ADAM Proteins- Therapeutic Potential in Cancer

1 Dec 2008

Abstract excerpt

The A Disintegrin And Metalloprotease (ADAM) proteins belong to the metzincin-superfamily of Zn-dependent metalloproteinases that shed the extracellular domains of membrane-bound growth factors, cytokines and their receptors. The latter play a central role in cell signaling and contribute a potential target in cancer therapy. Of particular interest are the ErBB/HER family of growth factor receptors associated...

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PMID: 19075595
DOI: 10.2174/156800908786733478

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