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Article

Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2016

Pham Christina D, Flores Catherine, Yang Changlin, Pinheiro Elaine M, Yearley Jennifer H, Sayour Elias J, Pei Yanxin, Moore Colin, McLendon Roger E, Huang Jianping, Sampson John H, Wechsler-Reya Robert, Mitchell Duane A

Abstract excerpt

PURPOSE: Despite significant strides in the identification and characterization of potential therapeutic targets for medulloblastoma, the role of the immune system and its interplay with the tumor microenvironment within these tumors are poorly understood. To address this, we adapted two syngeneic animal models of human Sonic Hedgehog (SHH)-driven and group 3 medulloblastoma for preclinical evaluation in...

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Identifiers

PMID: 26405194
DOI: 10.1158/1078-0432.CCR-15-0713
PMCID: PMC4922139

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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