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Sonic hedgehog functions upstream of<i>disrupted-in-schizophrenia 1</i>(<i>disc1</i>): implications for mental illness

24 Sept 2015

Abstract excerpt

DISRUPTED-IN-SCHIZOPHRENIA (DISC1) has been one of the most intensively studied genetic risk factors for mental illness since it was discovered through positional mapping of a translocation breakpoint in a large Scottish family where a balanced chromosomal translocation was found to segregate with schizophrenia and affective disorders. While the evidence for it being central to disease pathogenesis in the...

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PMID: 26405049
DOI: 10.1242/bio.012005

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