Article
A protein structural approach to the solution of biological problems: alpha 1-antitrypsin as a recent example.
The American journal of physiology - 1 Sept 1993
Lomas D A, Carrell R W
Abstract excerpt
alpha 1-Antitrypsin is a circulating serine proteinase inhibitor that protects the lungs against proteolysis by the enzyme neutrophil elastase. Most northern Europeans have only the normal M form, but some 4% are heterozygotes for the Z deficiency mutant. This mutant is characterized by the substitution of a positively charged lysine residue for a negatively charged glutamic acid at position 342 and results in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.