A protein structural approach to the solution of biological problems: alpha 1-antitrypsin as a recent example.

doi:10.1152/ajplung.1993.265.3.L211

Back to search

Article

A protein structural approach to the solution of biological problems: alpha 1-antitrypsin as a recent example.

The American journal of physiology - 1 Sept 1993

Lomas D A, Carrell R W

Abstract excerpt

alpha 1-Antitrypsin is a circulating serine proteinase inhibitor that protects the lungs against proteolysis by the enzyme neutrophil elastase. Most northern Europeans have only the normal M form, but some 4% are heterozygotes for the Z deficiency mutant. This mutant is characterized by the subst...

Topics

Animals
Crystallography
Humans
Liver
Mutation
Polymers
Protein Conformation
Structure-Activity Relationship
alpha 1-Antitrypsin

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.