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Article

The roles of helix I and strand 5A in the folding, function and misfolding of α1-antitrypsin.

PloS one - 1 Jan 2013

Knaupp Anja S, Keleher Shani, Yang Li, Dai Weiwen, Bottomley Stephen P, Pearce Mary C

Abstract excerpt

α(1)-Antitrypsin, the archetypal member of the serpin superfamily, is a metastable protein prone to polymerization when exposed to stressors such as elevated temperature, low denaturant concentrations or through the presence of deleterious mutations which, in a physiological context, are often associated with disease. Experimental evidence suggests that α(1)-Antitrypsin can polymerize via several alternative...

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Identifiers

PMID: 23382962
DOI: 10.1371/journal.pone.0054766
PMCID: PMC3558512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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