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Article

Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics.

eLife - 13 Nov 2012

Moin Syed M, Urban Sinisa

Abstract excerpt

Rhomboid proteases reside within cellular membranes, but the advantage of this unusual environment is unclear. We discovered membrane immersion allows substrates to be identified in a fundamentally-different way, based initially upon exposing 'masked' conformational dynamics of transmembrane segments rather than sequence-specific binding. EPR and CD spectroscopy revealed that the membrane restrains rhomboid gate...

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Identifiers

PMID: 23150798
DOI: 10.7554/eLife.00173
PMCID: PMC3494066

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