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Article

Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutions

1 Jun 1993

Abstract excerpt

Autoproteolysis of the retroviral aspartyl proteases is a major obstacle to purification and analysis of these enzymes. A mutagenic approach to rendering autolytic cleavage sites less labile was applied to the primary cleavage site between Leu5 and Trp6 in human immunodeficiency virus-1 (HIV-1) protease. From predictions based on known substrates it was concluded that amino acids Lys or Ser in place of Gln at...

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PMID: 8505318
DOI: 10.1016/s0021-9258(19)50290-3

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