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Article

Following autolysis in proteases by NMR: insights into multiple unfolding pathways and mutational plasticities.

Biophysical chemistry - 20 Aug 2006

Chatterjee Amarnath, Hosur Ramakrishna V

Abstract excerpt

Biophysical studies in proteases are severely hampered due to the auto-cleavage property of these enzymes. In this context, we develop here a kinetic model and an NMR-based strategy to use this very autolytic property to derive useful insights into multiple unfolding pathways and mutational plasticities in these proteins. The basic idea lies in the interpretation of the auto-cleavage-driven decay of the folded...

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Identifiers

PMID: 16647801
DOI: 10.1016/j.bpc.2006.03.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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