Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2

Abstract excerpt

Senescent cells show an altered secretome profile termed the senescence-associated secretory phenotype (SASP). There is an increasing body of evidence that suggests that the accumulation of SASP-positive senescent cells in humans is partially causal in the observed shift to a low-level pro-inflammatory state in aged individuals. This in turn suggests the SASP as a possible therapeutic target to ameliorate...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genetics, Aging, and Longevity in Model Organisms
• Share to Retinal Development and Disorders
• Share to Telomeres, Telomerase, and Senescence