Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype.

Abstract excerpt

Primary diploid cells exit the cell cycle in response to exogenous stress or oncogene activation through a process known as cellular senescence. This cell-autonomous tumor-suppressive mechanism is also a major mechanism operative in organismal aging. To date, temporal aspects of senescence remain understudied. Therefore, we use quantitative proteomics to investigate changes following forced HRASG12V expression...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cellular Senescence
• Share to Phenotype
• Share to Protein Isoforms