Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells

8 Oct 2012

Abstract excerpt

Neural stem cells (NSCs) are considered to be the cell of origin of glioblastoma multiforme (GBM). However, the genetic alterations that transform NSCs into glioma-initiating cells remain elusive. Using a unique transposon mutagenesis strategy that mutagenizes NSCs in culture, followed by additional rounds of mutagenesis to generate tumors in vivo, we have identified genes and signaling pathways that can...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Glioma Diagnosis and Treatment
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23045694
DOI: 10.1073/pnas.1215899109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cellsPMID 23045694Read ↗

<i>Sleeping Beauty</i> –Mediated Somatic Mutagenesis Implicates <i>CSF1</i> in the Formation of High-Grade AstrocytomasSemantic proximity Read ↗

Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal TumorsSemantic proximity Read ↗

From Neural Stem Cells (NSC) to Glioblastoma (GBM): A Natural History of GBM Recapitulated in VitroSemantic proximity Read ↗

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of GlioblastomaSemantic proximity Read ↗

From neural stem cells to glioblastoma: A natural history of GBM recapitulated in vitro.Semantic proximity Read ↗

Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survivalSemantic proximity Read ↗

A syngeneic glioblastoma mouse model with mesenchymal hallmarks.Semantic proximity Read ↗

Human glioblastoma arises from subventricular zone cells with low-level driver mutations.Semantic proximity Read ↗

Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide.Semantic proximity Read ↗

Gliomagenesis mimics an injury response orchestrated by neural crest-like cellsSemantic proximity Read ↗

AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma.Semantic proximity Read ↗

Direct <i>in vivo</i> mapping of functional suppressors in glioblastoma genomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.