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Article

Direct conversion of human pluripotent stem cells into cranial motor neurons using a piggyBac vector

26 Apr 2018

Abstract excerpt

Human pluripotent stem cells (PSCs) are widely used for in vitro disease modeling. One of the challenges in the field is represented by the ability of converting human PSCs into specific disease-relevant cell types. The nervous system is composed of a wide variety of neuronal types with selective vulnerability in neurodegenerative diseases. This is particularly relevant for motor neuron diseases, in which...

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PMID: 29729503
DOI: 10.1016/j.scr.2018.04.012

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