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Article

Histopathological spectrum of paediatric diffuse intrinsic pontine glioma: diagnostic and therapeutic implications.

Acta neuropathologica - 1 Oct 2014

Buczkowicz Pawel, Bartels Ute, Bouffet Eric, Becher Oren, Hawkins Cynthia

Abstract excerpt

Diffuse intrinsic pontine glioma (DIPG) is the main cause of brain tumour-related death in children. In the majority of cases diagnosis is based on clinical and MRI findings, resulting in the scarcity of pre-treatment specimens available to study. Our group has developed an autopsy-based protocol to investigate the histologic and biologic spectrum of DIPG. This has also allowed us to investigate the terminal...

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Source

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Identifiers

PMID: 25047029
DOI: 10.1007/s00401-014-1319-6
PMCID: PMC4159563

Genes

ACVR1
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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