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Article

Diffuse intrinsic pontine gliomas-current management and new biologic insights. Is there a glimmer of hope?

Neuro-oncology - 1 Aug 2017

Cohen Kenneth J, Jabado Nada, Grill Jacques

Abstract excerpt

Diffuse intrinsic pontine glioma (DIPG) has proven to be one of the most challenging of all pediatric cancers. Owing to a historical reticence to obtain tumor tissue for study, and based on an erroneous assumption that the biology of DIPG would mirror that of supratentorial high-grade astrocytomas, innumerable studies have been undertaken-all of which have had a negligible impact on the natural history of this...

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PMID: 28371920
DOI: 10.1093/neuonc/nox021
PMCID: PMC5570259

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