Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma.

doi:10.1038/ncomms11185

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Article

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma.

Nature communications - 6 Apr 2016

Nikbakht Hamid, Panditharatna Eshini, Mikael Leonie G, Li Rui, Gayden Tenzin, Osmond Matthew, Ho Cheng-Ying, Kambhampati Madhuri, Hwang Eugene I, Faury Damien, Siu Alan, Papillon-Cavanagh Simon, Bechet Denise, Ligon Keith L, Ellezam Benjamin, Ingram Wendy J, Stinson Caedyn, Moore Andrew S, Warren Katherine E, Karamchandani Jason, Packer Roger J, Jabado Nada, Majewski Jacek, Nazarian Javad

Abstract excerpt

Diffuse Intrinsic Pontine Gliomas (DIPGs) are deadly paediatric brain tumours where needle biopsies help guide diagnosis and targeted therapies. To address spatial heterogeneity, here we analyse 134 specimens from various neuroanatomical structures of whole autopsy brains from nine DIPG patients. Evolutionary reconstruction indicates histone 3 (H3) K27M--including H3.2K27M--mutations potentially arise first and...

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PMID: 27048880
DOI: 10.1038/ncomms11185
PMCID: PMC4823825

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ACVR1

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