Article
Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes.
Proceedings of the National Academy of Sciences of the United States of America - 4 Sept 2007
Woon Peng Y, Kaisaki Pamela J, Bragança José, Bihoreau Marie-Thérèse, Levy Jonathan C, Farrall Martin, Gauguier Dominique
Abstract excerpt
Many aspects of physiology and behavior follow a circadian rhythm. Brain and muscle Arnt-like protein-1 (BMAL1) is a key component of the mammalian molecular clock, which controls circadian oscillations. In the rat, the gene encoding Bmal1 is located within hypertension susceptibility loci. We analyzed the SNP distribution pattern in a congenic interval associated with hypertension in the spontaneously...
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