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Article

Conditional knockout of activin like kinase-1 (ALK-1) leads to heart failure without maladaptive remodeling.

Heart and vessels - 1 May 2017

Morine Kevin J, Qiao Xiaoying, Paruchuri Vikram, Aronovitz Mark J, Mackey Emily E, Buiten Lyanne, Levine Jonathan, Ughreja Keshan, Nepali Prerna, Blanton Robert M, Karas Richard H, Oh S Paul, Kapur Navin K

Abstract excerpt

Activin like kinase-1 (AlK-1) mediates signaling via the transforming growth factor beta (TGFβ) family of ligands. AlK-1 activity promotes endothelial proliferation and migration. Reduced AlK-1 activity is associated with arteriovenous malformations. No studies have examined the effect of global AlK-1 deletion on indices of cardiac remodeling. We hypothesized that reduced levels of AlK-1 promote maladaptive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28213819
DOI: 10.1007/s00380-017-0955-x
PMCID: PMC5410196

Genes

ALK
BMP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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