Article
High Frequency of Haplotype HLA-DQ7 in Celiac Disease Patients from South Italy: Retrospective Evaluation of 5,535 Subjects at Risk of Celiac Disease.
PloS one - 1 Jan 2015
Tinto Nadia, Cola Arturo, Piscopo Chiara, Capuano Marina, Galatola Martina, Greco Luigi, Sacchetti Lucia
Abstract excerpt
BACKGROUND: Celiac disease (CD) has a strong genetic component mainly due to HLA DQ2/DQ8 encoding genes. However, a minority of CD patients are DQ2/DQ8-negative. To address this issue, we retrospectively characterized HLA haplotypes in 5,535 subjects at risk of CD (either relatives of CD patients or subjects with CD-like symptoms) referred to our center during a 10-year period. METHODS: We identified loci...
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