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Article

Genetic variant of Interleukin-18 gene is associated with the Frailty Index in the English Longitudinal Study of Ageing.

Age and ageing - 1 Nov 2015

Mekli Krisztina, Marshall Alan, Nazroo James, Vanhoutte Bram, Pendleton Neil

Abstract excerpt

BACKGROUND: The term frailty refers to a condition of increased vulnerability to stressors among older people, leading to a decline in homeostatic reserve. Frailty often leads to falls, hospitalisation and mortality, hence its importance for the delivery of health care to older adults. The pathophysiological mechanisms behind frailty are not well understood, but the decreased steroid-hormone production and...

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Identifiers

PMID: 26396182
DOI: 10.1093/ageing/afv122
PMCID: PMC4621230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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