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Article

Frailty phenotype, genetic risk and long-term incident systemic lupus erythematosus risk: Insights from the UK Biobank study integrated with multi-omics analysis.

Clinical medicine (London, England) - 1 Jul 2026

Deng Peizhi, Yan Siyu, Lu Jianyun

Abstract excerpt

BACKGROUND: Frailty, a marker of biological ageing and reduced physiological reserve, is linked to many chronic conditions, yet its role in the development of systemic lupus erythematosus (SLE) remains unclear. AIMS: To examine the association between frailty and incident SLE and to investigate potential inflammatory and genetic mechanisms underlying this relationship. METHODS: We conducted a prospective cohort...

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Identifiers

PMID: 42242571
DOI: 10.1016/j.clinme.2026.100598
PMCID: PMC13314888

Genes

ANGPTL3
CST3
TNFSF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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