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Article

CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitis.

Oncotarget - 6 Oct 2015

Concepcion Axel R, Salas January T, Sáez Elena, Sarvide Sarai, Ferrer Alex, Portu Ainhoa, Uriarte Iker, Hervás-Stubbs Sandra, Oude Elferink Ronald P J, Prieto Jesús, Medina Juan F

Abstract excerpt

UNLABELLED: Primary biliary cirrhosis (PBC) is a chronic cholestatic disease of unknown etiopathogenesis showing progressive autoimmune-mediated cholangitis. In PBC patients, the liver and lymphocytes exhibit diminished expression of AE2/SLC4A2, a Cl-/HCO3- anion exchanger involved in biliary bicarbonate secretion and intracellular pH regulation. Decreased AE2 expression may be pathogenic as Ae2a,b(-/-) mice...

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Identifiers

PMID: 26396175
DOI: 10.18632/oncotarget.5665
PMCID: PMC4745679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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