Article
Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis.
Hepatology (Baltimore, Md.) - 1 Oct 2011
Tsuda Masanobu, Ambrosini Yoko M, Zhang Weici, Yang Guo-Xiang, Ando Yugo, Rong Guanghua, Tsuneyama Koichi, Sumida Kosuke, Shimoda Shinji, Bowlus Christopher L, Leung Patrick S C, He Xiao-Song, Coppel Ross L, Ansari Aftab A, Lian Zhe-Xiong, Gershwin M Eric
Abstract excerpt
UNLABELLED: In primary biliary cirrhosis (PBC), patients develop a multilineage response to a highly restricted peptide of the E2 component of pyruvate dehydrogenase (PDC-E2) involving autoantibody and autoreactive cluster of differentiation (CD)4(+) and CD8(+) T-cell responses. Recent data from murine models have suggested that liver-infiltrating CD8(+) cells play a critical role in biliary destruction in PBC....
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