Article

Ankrd11 deficiency reverses the dysfunction of chronic HBV-specific T-cell

2025-06-16

Abstract excerpt

<title>Abstract</title> <p>CD8<sup>+</sup> T cell dysfunction, driven by intricate molecular mechanisms, poses a major obstacle to hepatitis B virus (HBV) clearance in chronic infection. Using a highly humanized mouse model, we identified a T cell receptor (TCR) targeting a dominant epitope essential for HBV clearance in clinical settings. We further uncovered Ankrd11, an epigenetic regulator critical for sustain...

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Literature Corpus work: ce7846d9-7ee4-58d4-8658-d7606b30e7a1
DOI: 10.21203/rs.3.rs-6785364/v1

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