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Article

Apotopes and the biliary specificity of primary biliary cirrhosis†

30 Jan 2009

Abstract excerpt

UNLABELLED: Primary biliary cirrhosis (PBC) is characterized by antimitochondrial antibodies (AMAs), directed to the E2 component of the pyruvate dehydrogenase complex (PDC-E2). Notwithstanding the presence of mitochondria in virtually all nucleated cells, the destruction in PBC is limited to small intrahepatic bile ducts. The reasons for this tissue specificity remain unknown, although biliary epithelial cells...

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PMID: 19185000
DOI: 10.1002/hep.22736

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