Article
Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease.
Hepatology (Baltimore, Md.) - 1 Aug 2008
Wakabayashi Kanji, Lian Zhe-Xiong, Leung Patrick S C, Moritoki Yuki, Tsuneyama Koichi, Kurth Mark J, Lam Kit S, Yoshida Katsunori, Yang Guo-Xiang, Hibi Toshifumi, Ansari Aftab A, Ridgway William M, Coppel Ross L, Mackay Ian R, Gershwin M Eric
Abstract excerpt
UNLABELLED: There have been important advances in defining effector mechanisms for several human autoimmune diseases. However, for most human autoimmune diseases, the induction stage is less well defined and there are very few clues on etiology. Our laboratory has focused on defining the molecular basis of autoantibody recognition and epitope modification in primary biliary cirrhosis (PBC). Our work has...
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