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Article

Functional changes in the uterine artery precede the hypertensive phenotype in a transgenic model of hypertensive pregnancy.

American journal of physiology. Endocrinology and metabolism - 1 Nov 2015

Pulgar Victor M, Yamaleyeva Liliya M, Varagic Jasmina, McGee Carolynne, Bader Michael, Dechend Ralf, Brosnihan K Bridget

Abstract excerpt

The pregnant female human angiotensinogen (hAGN) transgenic rat mated with the male human renin (hREN) transgenic rat is a model of preeclampsia (TgA) with increased blood pressure, proteinuria, and placenta alterations of edema and necrosis at late gestation. We studied vascular responses and the role of COX-derived prostanoids in the uterine artery (UA) at early gestation in this model. TgA UA showed lower...

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Identifiers

PMID: 26394667
DOI: 10.1152/ajpendo.00526.2014
PMCID: PMC4628942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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