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Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia

7 Nov 2016

Abstract excerpt

, improves the maternal condition, prolongs pregnancies, and prevents FGR in two contrasting mouse models of PE. The first is caused by endotheliosis due to excess levels in the mothers of a soluble form of the receptor for vascular endothelial growth factor (VEGF), which binds to and inactivates VEGF. The second is caused by genetic absence of Ankiryn-repeat-and-SOCS-box-containing-protein 4, a factor that...

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PMID: 27821757
DOI: 10.1073/pnas.1614947113

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