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Article

Haplotypes at LBX1 have distinct inheritance patterns with opposite effects in adolescent idiopathic scoliosis.

PloS one - 1 Jan 2015

Chettier Rakesh, Nelson Lesa, Ogilvie James W, Albertsen Hans M, Ward Kenneth

Abstract excerpt

Adolescent idiopathic scoliosis (AIS) is a clinically significant disorder with high heritability that affects 2-4% of the population. Genome-wide association studies have identified LBX1 as a strong susceptibility locus for AIS in Asian and Caucasian populations. Here we further dissect the genetic association with AIS in a Caucasian population. To identify genetic markers associated with AIS we employed a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25675428
DOI: 10.1371/journal.pone.0117708
PMCID: PMC4326419

Genes

LBX1

Provenance

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Related research

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Research trail→

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Haplotypes at LBX1 have distinct inheritance patterns with opposite effects in adolescent idiopathic scoliosis.PMID 25675428Read ↗

A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups.Semantic proximity Read ↗

The association of rs11190870 near LBX1 with the susceptibility and severity of AIS, a meta-analysis.Semantic proximity Read ↗

Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis in East Asians: a systematic review and meta-analysis.Semantic proximity Read ↗

A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis.Semantic proximity Read ↗

Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls.Semantic proximity Read ↗

A Replication Study for Association of LBX1 Locus With Adolescent Idiopathic Scoliosis in French-Canadian Population.Semantic proximity Read ↗

Associations of LBX1 gene and adolescent idiopathic scoliosis susceptibility: a meta-analysis based on 34,626 subjects.Semantic proximity Read ↗

Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis.Semantic proximity Read ↗

Association between genetic polymorphisms and risk of adolescent idiopathic scoliosis in case-control studies: a systematic review.Semantic proximity Read ↗

Association between common variants near LBX1 and adolescent idiopathic scoliosis replicated in the Chinese Han population.Semantic proximity Read ↗

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Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population.Semantic proximity Read ↗

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