Article
A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis.
Nature genetics - 23 Oct 2011
Takahashi Yohei, Kou Ikuyo, Takahashi Atsushi, Johnson Todd A, Kono Katsuki, Kawakami Noriaki, Uno Koki, Ito Manabu, Minami Shohei, Yanagida Haruhisa, Taneichi Hiroshi, Tsuji Taichi, Suzuki Teppei, Sudo Hideki, Kotani Toshiaki, Watanabe Kota, Chiba Kazuhiro, Hosono Naoya, Kamatani Naoyuki, Tsunoda Tatsuhiko, Toyama Yoshiaki, Kubo Michiaki, Matsumoto Morio, Ikegawa Shiro
Abstract excerpt
Adolescent idiopathic scoliosis is a pediatric spinal deformity affecting 2-3% of school-age children worldwide(1). Genetic factors have been implicated in its etiology(2). Through a genome-wide association study (GWAS) and replication study involving a total of 1,376 Japanese females with adolescent idiopathic scoliosis and 11,297 female controls, we identified a locus at chromosome 10q24.31 associated with...
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