Article
Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA.
PloS one - 1 Jan 2015
Doritchamou Justin, Sabbagh Audrey, Jespersen Jakob S, Renard Emmanuelle, Salanti Ali, Nielsen Morten A, Deloron Philippe, Tuikue Ndam Nicaise
Abstract excerpt
The VAR2CSA protein of Plasmodium falciparum is transported to and expressed on the infected erythrocyte surface where it plays a key role in placental malaria (PM). It is the current leading candidate for a vaccine to prevent PM. However, the antigenic polymorphism integral to VAR2CSA poses a challenge for vaccine development. Based on detailed analysis of polymorphisms in the sequence of its ligand-binding...
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