Article
Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration.
PLoS pathogens - 1 Nov 2006
Dahlbäck Madeleine, Rask Thomas S, Andersen Pernille H, Nielsen Morten A, Ndam Nicaise T, Resende Mafalda, Turner Louise, Deloron Philippe, Hviid Lars, Lund Ole, Pedersen Anders Gorm, Theander Thor G, Salanti Ali
Abstract excerpt
Pregnancy-associated malaria is a major health problem, which mainly affects primigravidae living in malaria endemic areas. The syndrome is precipitated by accumulation of infected erythrocytes in placental tissue through an interaction between chondroitin sulphate A on syncytiotrophoblasts and a parasite-encoded protein on the surface of infected erythrocytes, believed to be VAR2CSA. VAR2CSA is a polymorphic...
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