Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: impact on vaccine design for placental malaria.

doi:10.1016/j.meegid.2014.04.010

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: impact on vaccine design for placental malaria.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jul 2014

Bordbar Bita, Tuikue Ndam Nicaise, Renard Emmanuelle, Jafari-Guemouri Sayeh, Tavul Livingstone, Jennison Charlie, Gnidehou Sédami, Tahar Rachida, Gamboa Dionicia, Bendezu Jorge, Menard Didier, Barry Alyssa E, Deloron Philippe, Sabbagh Audrey

Abstract excerpt

In placental malaria (PM), sequestration of infected erythrocytes in the placenta is mediated by an interaction between VAR2CSA, a Plasmodium falciparum protein expressed on erythrocytes, and chondroitin sulfate A (CSA) on syncytiotrophoblasts. Recent works have identified ID1-DBL2Xb as the minimal CSA-binding region within VAR2CSA able to induce strong protective immunity, making it the leading candidate for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigenic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antigens, Protozoan

Share to DNA, Protozoan

Share to Malaria, Falciparum

Share to Placenta

Share to Plasmodium falciparum

Share to Pregnancy Complications, Parasitic

Share to Viral Vaccines

Source

Open in PubMed

Identifiers

PMID: 24768682
DOI: 10.1016/j.meegid.2014.04.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: impact on vaccine design for placental malaria.PMID 24768682Read ↗

Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine developmentSemantic proximity Read ↗

Structural insights into global mutations in the ligand-binding domain of VAR2CSA and its implications on placental malaria vaccine.Semantic proximity Read ↗

A systematic review on genetic diversity of var gene DBL1α domain from different geographical regions in Plasmodium falciparum isolates.Semantic proximity Read ↗

Genetic analysis of ID1-DBL2X predicts its validity as a vaccine candidate in Colombia and supports at least two independently introduced Plasmodium falciparum populations in the region.Semantic proximity Read ↗

Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration.Semantic proximity Read ↗

Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strainsSemantic proximity Read ↗

Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA.Semantic proximity Read ↗

Induction of Adhesion-Inhibitory Antibodies against Placental<i>Plasmodium falciparum</i>Parasites by Using Single Domains of VAR2CSASemantic proximity Read ↗

Two divergent VAR2CSA lineages with distinct evolutionary signatures circulate in Plasmodium falciparum from Thailand.Semantic proximity Read ↗

Evaluation of the Antigenic Diversity of Placenta-Binding Plasmodium falciparum Variants and the Antibody Repertoire among Pregnant WomenSemantic proximity Read ↗

Evidence for Globally Shared, Cross-Reacting Polymorphic Epitopes in the Pregnancy-Associated Malaria Vaccine Candidate VAR2CSASemantic proximity Read ↗

Extreme Genetic Diversity and Signatures of Balancing Selection in Plasmodium vivax Blood-Stage Antigens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.