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Article

Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade.

Scientific reports - 11 Aug 2017

Patel Jaymin C, Hathaway Nicholas J, Parobek Christian M, Thwai Kyaw L, Madanitsa Mwayiwawo, Khairallah Carole, Kalilani-Phiri Linda, Mwapasa Victor, Massougbodji Achille, Fievet Nadine, Bailey Jeffery A, Ter Kuile Feiko O, Deloron Philippe, Engel Stephanie M, Taylor Steve M, Juliano Jonathan J, Tuikue Ndam Nicaise, Meshnick Steven R

Abstract excerpt

Pregnancy associated malaria (PAM) causes adverse pregnancy and birth outcomes owing to Plasmodium falciparum accumulation in the placenta. Placental accumulation is mediated by P. falciparum protein VAR2CSA, a leading PAM-specific vaccine target. The extent of its antigen diversity and impact on clinical outcomes remain poorly understood. Through amplicon deep-sequencing placental malaria samples from women in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28801627
DOI: 10.1038/s41598-017-04737-y
PMCID: PMC5554196

Genes

PAM

Provenance

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Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade.PMID 28801627Read ↗

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