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Article

Structural insights into global mutations in the ligand-binding domain of VAR2CSA and its implications on placental malaria vaccine.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Nov 2021

Gill Jasmita, Chakraborti Soumyananda, Bharti Praveen, Sharma Amit

Abstract excerpt

Placental malaria is a public health burden particularly in Africa as it causes severe symptoms and results in stillbirths or maternal deaths. Plasmodium falciparum protein VAR2CSA drives placental malaria (PM) in pregnant women by adhering to chondroitin sulfate A (CSA) on the placenta. VAR2CSA is a primary vaccine candidate for PM with two vaccines based on it already under clinical trials. The first cryo-EM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34450283
DOI: 10.1016/j.ijid.2021.08.054

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Structural insights into global mutations in the ligand-binding domain of VAR2CSA and its implications on placental malaria vaccine.PMID 34450283Read ↗

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