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Article

Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA.

PLoS pathogens - 8 Feb 2008

Andersen Pernille, Nielsen Morten A, Resende Mafalda, Rask Thomas S, Dahlbäck Madeleine, Theander Thor, Lund Ole, Salanti Ali

Abstract excerpt

Pregnancy-associated malaria is caused by Plasmodium falciparum malaria parasites binding specifically to chondroitin sulfate A in the placenta. This sequestration of parasites is a major cause of low birth weight in infants and anemia in the mothers. VAR2CSA, a polymorphic multi-domain protein of the PfEMP1 family, is the main parasite ligand for CSA binding, and identification of protective antibody epitopes is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18282103
DOI: 10.1371/journal.ppat.0040042
PMCID: PMC2242842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA.PMID 18282103Read ↗

Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration.Semantic proximity Read ↗

Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.Semantic proximity Read ↗

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinitySemantic proximity Read ↗

Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions.Semantic proximity Read ↗

Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA.Semantic proximity Read ↗

Induction of Adhesion-Inhibitory Antibodies against Placental<i>Plasmodium falciparum</i>Parasites by Using Single Domains of VAR2CSASemantic proximity Read ↗

Structural insights into global mutations in the ligand-binding domain of VAR2CSA and its implications on placental malaria vaccine.Semantic proximity Read ↗

Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA.Semantic proximity Read ↗

Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine developmentSemantic proximity Read ↗

Evidence for Globally Shared, Cross-Reacting Polymorphic Epitopes in the Pregnancy-Associated Malaria Vaccine Candidate VAR2CSASemantic proximity Read ↗

Structural and immunological correlations between the variable blocks of the VAR2CSA domain DBL6ε from two Plasmodium falciparum parasite lines.Semantic proximity Read ↗

Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate bindingSemantic proximity Read ↗

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