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An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking

21 Sept 2015

Abstract excerpt

Microvillus inclusion disease (MVID) is a rare intestinal enteropathy with an onset within a few days to months after birth, resulting in persistent watery diarrhea. Mutations in the myosin Vb gene (MYO5B) have been identified in the majority of MVID patients. However, the exact pathophysiology of MVID still remains unclear. To address the specific role of MYO5B in the intestine, we generated an...

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PMID: 26392529
DOI: 10.1073/pnas.1516672112

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