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Article

Identification of intestinal ion transport defects in microvillus inclusion disease.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jul 2016

Kravtsov Dmitri V, Ahsan Md Kaimul, Kumari Vandana, van Ijzendoorn Sven C D, Reyes-Mugica Miguel, Kumar Anoop, Gujral Tarunmeet, Dudeja Pradeep K, Ameen Nadia A

Abstract excerpt

Loss of function mutations in the actin motor myosin Vb (Myo5b) lead to microvillus inclusion disease (MVID) and death in newborns and children. MVID results in secretory diarrhea, brush border (BB) defects, villus atrophy, and microvillus inclusions (MVIs) in enterocytes. How loss of Myo5b results in increased stool loss of chloride (Cl(-)) and sodium (Na(+)) is unknown. The present study used Myo5b...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27229121
DOI: 10.1152/ajpgi.00041.2016
PMCID: PMC4967175

Genes

CFTR
YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Identification of intestinal ion transport defects in microvillus inclusion disease.PMID 27229121Read ↗

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