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Article

Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease.

Digestive diseases and sciences - 1 Feb 2018

Schlegel Cameron, Weis Victoria G, Knowles Byron C, Lapierre Lynne A, Martin Martin G, Dickman Paul, Goldenring James R, Shub Mitchell D

Abstract excerpt

OBJECTIVES: Microvillus inclusion disease (MVID) is a severe form of neonatal diarrhea, caused mainly by mutations in MYO5B. Inactivating mutations in MYO5B causes depolarization of enterocytes in the small intestine, which gives rise to chronic, unremitting secretory diarrhea. While the pathology of the small intestine in MVID patients is well described, little is known about extraintestinal effects of MYO5B...

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Identifiers

PMID: 29218485
DOI: 10.1007/s10620-017-4867-5
PMCID: PMC5797493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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