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Article

Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.

The Journal of clinical investigation - 1 Jul 2014

Knowles Byron C, Roland Joseph T, Krishnan Moorthy, Tyska Matthew J, Lapierre Lynne A, Dickman Paul S, Goldenring James R, Shub Mitchell D

Abstract excerpt

Microvillus inclusion disease (MVID) is a severe form of congenital diarrhea that arises from inactivating mutations in the gene encoding myosin Vb (MYO5B). We have examined the association of mutations in MYO5B and disruption of microvillar assembly and polarity in enterocytes. Stable MYO5B knockdown (MYO5B-KD) in CaCo2-BBE cells elicited loss of microvilli, alterations in junctional claudins, and disruption of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24892806
DOI: 10.1172/JCI71651
PMCID: PMC4071383

Genes

SNX18

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Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.PMID 24892806Read ↗

Altered MYO5B Function Underlies Microvillus Inclusion Disease: Opportunities for Intervention at a Cellular LevelSemantic proximity Read ↗

Microvillus inclusion disease: loss of Myosin vb disrupts intracellular traffic and cell polarity.Semantic proximity Read ↗

Identification of intestinal ion transport defects in microvillus inclusion disease.Semantic proximity Read ↗

Loss of MYO5B in Mice Recapitulates Microvillus Inclusion Disease and Reveals an Apical Trafficking Pathway Distinct to Neonatal DuodenumSemantic proximity Read ↗

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral traffickingSemantic proximity Read ↗

Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease.Semantic proximity Read ↗

Myo5b knockout mice as a model of microvillus inclusion diseaseSemantic proximity Read ↗

Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment.Semantic proximity Read ↗

Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease.Semantic proximity Read ↗

Recent advances in understanding and managing malabsorption: focus on microvillus inclusion diseaseSemantic proximity Read ↗

UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking.Semantic proximity Read ↗

Congenital Diarrhea and Cholestatic Liver Disease: Phenotypic Spectrum Associated with MYO5B MutationsSemantic proximity Read ↗

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