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Article

Myo5b knockout mice as a model of microvillus inclusion disease

23 Jul 2015

Abstract excerpt

Inherited MYO5B mutations have recently been associated with microvillus inclusion disease (MVID), an autosomal recessive syndrome characterized by intractable, life-threatening, watery diarrhea appearing shortly after birth. Characterization of the molecular mechanisms underlying this disease and development of novel therapeutic approaches is hampered by the lack of animal models. In this study we describe the...

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PMID: 26201991
DOI: 10.1038/srep12312

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