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Article

Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment.

American journal of physiology. Gastrointestinal and liver physiology - 15 Nov 2014

Kravtsov Dmitri, Mashukova Anastasia, Forteza Radia, Rodriguez Maria M, Ameen Nadia A, Salas Pedro J

Abstract excerpt

Microvillus inclusion disease (MVID) is an autosomal recessive condition resulting in intractable secretory diarrhea in newborns due to loss-of-function mutations in myosin Vb (Myo5b). Previous work suggested that the apical recycling endosomal (ARE) compartment is the primary location for phosphoinositide-dependent protein kinase 1 (PDK1) signaling. Because the ARE is disrupted in MVID, we tested the hypothesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25258405
DOI: 10.1152/ajpgi.00180.2014
PMCID: PMC4233287

Genes

PDK1

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Related research

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Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment.PMID 25258405Read ↗

Altered MYO5B Function Underlies Microvillus Inclusion Disease: Opportunities for Intervention at a Cellular LevelSemantic proximity Read ↗

Microvillus inclusion disease: loss of Myosin vb disrupts intracellular traffic and cell polarity.Semantic proximity Read ↗

Identification of intestinal ion transport defects in microvillus inclusion disease.Semantic proximity Read ↗

Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.Semantic proximity Read ↗

Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease.Semantic proximity Read ↗

Therapy Development for Microvillus Inclusion Disease using Patient-derived EnteroidsSemantic proximity Read ↗

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral traffickingSemantic proximity Read ↗

Recent advances in understanding and managing malabsorption: focus on microvillus inclusion diseaseSemantic proximity Read ↗

Altered cellular metabolic pathway and epithelial cell maturation induced by MYO5B defects are partially reversible by LPAR5 activationSemantic proximity Read ↗

Myosin Vb Traffics P-Glycoprotein to the Apical Membrane of Intestinal Epithelial Cells.Semantic proximity Read ↗

Loss of MYO5B in Mice Recapitulates Microvillus Inclusion Disease and Reveals an Apical Trafficking Pathway Distinct to Neonatal DuodenumSemantic proximity Read ↗

Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease.Semantic proximity Read ↗

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