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Article

Microvillus inclusion disease: loss of Myosin vb disrupts intracellular traffic and cell polarity.

Traffic (Copenhagen, Denmark) - 1 Jan 2014

Thoeni Cornelia E, Vogel Georg F, Tancevski Ivan, Geley Stephan, Lechner Silvia, Pfaller Kristian, Hess Michael W, Müller Thomas, Janecke Andreas R, Avitzur Yaron, Muise Aleixo, Cutz Ernest, Huber Lukas A

Abstract excerpt

Microvillus inclusion disease (MVID) is a congenital enteropathy characterized by loss of apical microvilli and formation of cytoplasmic inclusions lined by microvilli in enterocytes. MVID is caused by mutations in the MYO5B gene, coding for the myosin Vb motor protein. Although myosin Vb is implicated in the organization of intracellular transport and cell surface polarity in epithelial cells, its precise role...

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Identifiers

PMID: 24138727
DOI: 10.1111/tra.12131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Microvillus inclusion disease: loss of Myosin vb disrupts intracellular traffic and cell polarity.PMID 24138727Read ↗

Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.Semantic proximity Read ↗

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Altered MYO5B Function Underlies Microvillus Inclusion Disease: Opportunities for Intervention at a Cellular LevelSemantic proximity Read ↗

Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment.Semantic proximity Read ↗

Loss of MYO5B in Mice Recapitulates Microvillus Inclusion Disease and Reveals an Apical Trafficking Pathway Distinct to Neonatal DuodenumSemantic proximity Read ↗

Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease.Semantic proximity Read ↗

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The zebrafish goosepimples/myosin Vb mutant exhibits cellular attributes of human microvillus inclusion disease.Semantic proximity Read ↗

Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease.Semantic proximity Read ↗

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