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Article

Focal Ischemic Injury with Complex Middle Cerebral Artery in Stroke-Prone Spontaneously Hypertensive Rats with Loss-Of-Function in NADPH Oxidases.

PloS one - 1 Jan 2015

Yao Hiroshi, Ferdaus Mohammed Zubaerul, Zahid Hasan Md, Ohara Hiroki, Nakahara Tatsuo, Nabika Toru

Abstract excerpt

By means of introgressing a loss-of-function mutation in the p22phox gene from the Matsumoto Eosinophilia Shinshu (MES) rat to stroke-prone spontaneously hypertensive rats (SHRSP), we constructed the SHRSP-based congenic strain lacking the P22PHOX expression (i.e., lacking NADPH oxidases [NOX] activities) (SHRSP.MES-Cyba(mes)/Izm; hereafter referred to as SP.MES). To examine the effects of Nox activities on the...

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Source

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Identifiers

PMID: 26389812
DOI: 10.1371/journal.pone.0138551
PMCID: PMC4577106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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