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Animal models of ischemic cerebral small vessel disease: A narrative review of pathological phenotypes, challenges, and future directions.

Experimental neurology - 1 Nov 2026

Cui Jingyu, Zhong Jing, Wang Youjie, Shang Wenzuo, Yan Yuying, Lan Tianxiang, Wu Bo, Jiang Shuai

Abstract excerpt

Cerebral small vessel disease (CSVD) is a leading cause of vascular cognitive impairment and stroke, yet its pathophysiology remains incompletely understood and effective treatments are lacking. This narrative review focuses on animal models that recapitulate the ischemic phenotypes of CSVD, including white matter lesions, lacunar infarcts, and chronic cerebral hypoperfusion; hemorrhagic CSVD subtypes are not...

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PMID: 42532135
DOI: 10.1016/j.expneurol.2026.115947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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