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Article

Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.

Structure (London, England : 1993) - 3 Nov 2015

Yin Jianping, Schoeffler Allyn J, Wickliffe Katherine, Newton Kim, Starovasnik Melissa A, Dueber Erin C, Harris Seth F

Abstract excerpt

Protein ubiquitination patterns are an important component of cellular signaling. The WD-repeat protein WDR48 (USP1-associated factor UAF-1) stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46. To understand how WDR48 exerts its effect on the USP scaffold, we determined structures of the ternary WDR48:USP46:ubiquitin complex. WDR48 interacts with the USP46 fingers subdomain via a relatively...

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Identifiers

PMID: 26388029
DOI: 10.1016/j.str.2015.08.010

Genes

USP46
USP1
USP12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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