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Article

Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain.

Communications biology - 8 Nov 2021

Kakihara Keijun, Asamizu Kengo, Moritsugu Kei, Kubo Masahide, Kitaguchi Tetsuya, Endo Akinori, Kidera Akinori, Ikeguchi Mitsunori, Kato Akira, Komada Masayuki, Fukushima Toshiaki

Abstract excerpt

Ubiquitin-specific protease 8 (USP8) is a deubiquitinating enzyme involved in multiple membrane trafficking pathways. The enzyme activity is inhibited by binding to 14-3-3 proteins. Mutations in the 14-3-3-binding motif in USP8 are related to Cushing's disease. However, the molecular basis of USP8 activity regulation remains unclear. This study identified amino acids 645-684 of USP8 as an autoinhibitory region,...

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Identifiers

PMID: 34750505
DOI: 10.1038/s42003-021-02802-x
PMCID: PMC8576004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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