Article

The molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain

2021-05-31

Abstract excerpt

Ubiquitin-specific protease 8 (USP8) is a deubiquitinating enzyme involved in multiple membrane trafficking pathways. The enzyme activity is inhibited by binding to 14-3-3 proteins, and mutations of the 14-3-3 binding motif in USP8 are related to Cushing’s disease. However, the molecular basis of USP8 enzyme activity regulation remains unclear. Here, we identified amino acids 645–684 of USP8 as an autoinhibitory r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1fb8c4db-5931-5a74-a730-5b1526122756
DOI: 10.1101/2021.05.31.446389

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domainDOI 10.1101/2021.05.31.446389Read

Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain.Semantic proximity Read

Molecular bases for USP48 cis-activity regulation and hyperactivation by Cushing's disease-associated mutationsSemantic proximity Read

Ubiquitin-specific protease 8 (USP8/UBPy): a prototypic multidomain deubiquitinating enzyme with pleiotropic functions.Semantic proximity Read

USP8 Mutations Associated with Cushing's Disease Alter Protein Structure Dynamics.Semantic proximity Read

Recent advances in understanding Cushing disease: resistance to glucocorticoid negative feedback and somatic USP8 mutationsSemantic proximity Read

Recurrent gain-of-function USP8 mutations in Cushing's diseaseSemantic proximity Read

Functional spectrum of USP7 pathogenic variants in Hao-Fountain syndrome: Insights into the enzyme's activity, stability, and allosteric modulation.Semantic proximity Read

The New Genetic Landscape of Cushing’s Disease: Deubiquitinases in the SpotlightSemantic proximity Read

Mutations in the deubiquitinase gene USP8 cause Cushing's disease.Semantic proximity Read

Driver mutations in USP8 wild-type Cushing’s diseaseSemantic proximity Read

Functional Spectrum of USP7 Pathogenic Variants in Hao-Fountain Syndrome: Insights into the Enzyme’s Activity, Stability, and Allosteric ModulationSemantic proximity Read

Emerging insights into HAUSP (USP7) in physiology, cancer and other diseasesSemantic proximity Read