Article

Surprising variety in the USP deubiquitinase catalytic mechanism

2023-07-24

Abstract excerpt

The USP family of deubiquitinases (DUBs) controls many ubiquitin-dependent signaling events. This generates therapeutic potential, with active-site inhibitors in preclinical and clinical studies. Understanding of the USP active site was so far primarily guided by USP7 data, where the catalytic triad consists of cysteine, histidine and a third residue (first critical residue), which polarizes the histidine through...

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Literature Corpus work: 371cef0c-8f5a-5c2d-8ee4-b199bd149302
DOI: 10.1101/2023.07.24.550302

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