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Article

Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting.

Nature structural & molecular biology - 1 Mar 2006

Hirano Satoshi, Kawasaki Masato, Ura Hideaki, Kato Ryuichi, Raiborg Camilla, Stenmark Harald, Wakatsuki Soichi

Abstract excerpt

Hrs has an essential role in sorting of monoubiquitinated receptors to multivesicular bodies for lysosomal degradation, through recognition of ubiquitinated receptors by its ubiquitin-interacting motif (UIM). Here, we present the structure of a complex of Hrs-UIM and ubiquitin at 1.7-A resolution. Hrs-UIM forms a single alpha-helix, which binds two ubiquitin molecules, one on either side. These two ubiquitin...

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PMID: 16462748
DOI: 10.1038/nsmb1051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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