Transcriptional Regulators YAP and TAZ Have Distinct Abilities to Compensate for One Another in Podocytes

Abstract excerpt

Key Points Podocyte-specific knockout of YAP but not TAZ led to proteinuria. Knockout of more than two alleles of YAP and TAZ resulted in neonatal death, revealing compensation between the two cotranscription factors. Although YAP fully compensated for the loss of TAZ, TAZ did not entirely compensate for YAP functions related to Rho-GTPase and ERBB4 signaling. Background Kidney function depends on the filtration...